Endocrine Abstracts

Introduction: Prolactin is a multifunctional pituitary hormone. The effect of prolactin on platelet activation is not well understood. Prolactinomas are the most common type of pituitary adenomas, and they are medically responsive to dopamine agonists. Mean platelet volume (MPV) is a marker of platelet function and activation. The aim of this study was to evaluate MPV values before and 6 months of cabergoline treatment when normoprolactinemia was achieved.<p class="abstext...

Introduction: Primary hyperparathyroidism (PHPT) is a common endocrine disorder. However, a familial hyperparathyroid syndrome is diagnosed in less than 5% of cases. We present two related cases of CDC73-related familial hyperparathyroidism due to a rarely described germline Leu63Pro missense mutation in CDC73 exon 2.Case report: The index patient, a 24-year-old female, presented acutely unwell with symptoms of hypercalcaemia. Her blood...

Objectives: The present study investigate the effect of light at night and rotating shift on circadian pattern of salivary cortisol and melatonin sulphate level in night shift workers and to find out whether these changes in the circadian pattern produce by night shift are reversible in due course of time. Sleep loss may be a novel risk factor for various hormones and sleep disturbances leads to metabolic and endocrinal disorders due to interference with diet, circadian metabo...

Despite advances in neurosurgical techniques, due to their size and their readily invasive nature, surgical resection of functional or non-functional pituitary macroadenomas is often only partial, justifying the use of any additional treatment (resumption of surgery, radiotherapy, treatment drug).Patients and Methods: 10 patients were included in the study (7 men middle-aged 56 and 3 women middle-aged 48). 4 patients followed for non-functional pituitary...

Introduction: We submit a rare presentation of pheaochromocytoma in pregnanacy, diagnosed just before delivery, posing complex management difficulties.Case presentationA 24-year-old primipara had headache, hypertension and visual disturbance but without any palpitations or diaphoresis. Her headache was persistent during pregnancy. Investigations at 39 weeks of gestation showed normal plasma Normetadrenaline at 885.0 (120–1180)...

Introduction: Graves’ thyrotoxicosis and Addison’s disease are disorders with a strong auto-immune basis. Primary hypothyroidism and Addison’s disease are recognised components of polyglandular autoimmune syndrome type II (PGA-II). Despite its autoimmune etiology, Graves disease is not commonly associated with PGA-II. We present a case of a patient with newly diagnosed Graves’ disease presenting in incipient adrenal crisis due to unrecognized Addison’s...

Introduction: Non-islet cell tumour hypoglycaemia (NICTH) is an uncommon but serious complication of disseminated malignancy. The underlying aetiology of hypoglycaemia is tumoral overproduction of IGF2, which results in stimulation of insulin receptors and increased glucose utilization. Extensive tumour burden involving the liver and adrenal glands can also cause severe hypoglycaemia.Case report: An 80-year-old man presented acutely in an unresponsive st...

Introduction: Hypothalamic–pituitary sarcoidosis is uncommon and affects <10% of patients with neurosarcoidosis. It presents a diagnostic challenge. We present a case of isolated central hypoadrenalism presenting as the sole manifestation of neurosarcoidosis.Case history: A 76-year-old man with recently diagnosed primary hypothyroidism presented with weight loss, increasing lethargy and fatigue. Physical exam revealed inguinal lymhadenopathy. St...

A nineteen year old man was admitted by his GP with profound weight loss. He had avoided contact with primary care services as he feared doctors, but had been referred to an eating disorders clinic. He had a diet of exclusively snack food and had been losing weight for two years.On examination he was cachectic and pale with scanty body hair. His body mass index was 13 kg/m2, with a weight of 44 kg. He was clinically thyrotoxic, a small diffuse...

Background: Adrenal incidentalomas (AI) are common, with approximately 40% of these demonstrating evidence of mild autonomous cortisol secretion (MACS). MACS has been associated with increased morbidity and mortality, and some patients with MACS may benefit from medical therapy or adrenalectomy, so all require further evaluation. Given the large numbers of patients involved, this has potentially significant resource implications for outpatient endocrinology se...